MAPK Phosphatase-1 Deficiency Exacerbates the Severity of Imiquimod-Induced Psoriasiform Skin Disease

MAPK Phosphatase-1 Deficiency Exacerbates the Severity of Imiquimod-Induced Psoriasiform Skin Disease

Persistent activation of mitogen-activated protein kinase (MAPK) is believed to be involved in psoriasis pathogenesis. MAPK phosphatase-1 (MKP-1) is an important negative regulator of MAPK activity, but the cellular and molecular mechanisms of MKP-1 in psoriasis development are largely unknown. In t...

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Bibliographic Details
Main Authors: Weiheng Zhao, Shuxiu Xiao, Hongjin Li, Tingting Zheng, Jian Huang, Ran Hu, Baohua Zhang, Xinguang Liu, Gonghua Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
mitogen-activated protein kinase
phosphatase MAPK phosphatase-1
psoriasis
macrophage
keratinocyte
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00569/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00569/full

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