Mutation Test in Korean Patients with Colorectal Carcinomas: A Methodological Comparison between Sanger Sequencing and a Real-Time PCR-Based Assay

Mutation Test in Korean Patients with Colorectal Carcinomas: A Methodological Comparison between Sanger Sequencing and a Real-Time PCR-Based Assay

Background Mutations in the KRAS gene have been identified in approximately 50% of colorectal cancers (CRCs). KRAS mutations are well established biomarkers in anti–epidermal growth factor receptor therapy. Therefore, assessment of KRAS mutations is needed in CRC patients to ensure appropriate treat...

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Bibliographic Details
Main Authors: Sung Hak Lee, Arthur Minwoo Chung, Ahwon Lee, Woo Jin Oh, Yeong Jin Choi, Youn-Soo Lee, Eun Sun Jung
Format: Article
Language:English
Published: Korean Society of Pathologists & the Korean Society for Cytopathology 2017-01-01
Series:Journal of Pathology and Translational Medicine
Subjects:
KRAS mutation test
Sanger sequencing
Cobas test
454 pyrosequencing
Online Access:http://www.jpatholtm.org/upload/pdf/jptm-2016-10-03.pdf

Internet

http://www.jpatholtm.org/upload/pdf/jptm-2016-10-03.pdf

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