Novel Molecular Signatures in the PIP4K/PIP5K Family of Proteins Specific for Different Isozymes and Subfamilies Provide Important Insights into the Evolutionary Divergence of this Protein Family

Novel Molecular Signatures in the PIP4K/PIP5K Family of Proteins Specific for Different Isozymes and Subfamilies Provide Important Insights into the Evolutionary Divergence of this Protein Family

Members of the PIP4K/PIP5K family of proteins, which generate the highly important secondary messenger phosphatidylinositol-4,5-bisphosphate, play central roles in regulating diverse signaling pathways. In eukaryotic organisms, multiple isozymes and subfamilies of PIP4K/PIP5K proteins are found and...

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Bibliographic Details
Main Authors: Bijendra Khadka, Radhey S. Gupta
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Genes
Subjects:
phosphatidylinositol phosphate kinases
conserved signature indels
molecular signatures for the pip4k/pip5k isozymes and isoforms
phylogenetic analysis
species distribution of pip4k/pip5k proteins
holozoa clade of eukaryotic organisms
evolution of the PIP4K/PIP5K family of proteins
protein evolution
Online Access:https://www.mdpi.com/2073-4425/10/4/312

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https://www.mdpi.com/2073-4425/10/4/312

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