Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells

Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells

Toxoplasma gondii is an important human and animal pathogen that causes life-threatening toxoplasmosis. Interferon-γ (IFN-γ) is critical for anti-T. gondii cell-autonomous immunity in both humans and mice. To proliferate efficiently within the hosts, virulent strains of T. gondii can suppress IFN-γ-...

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Bibliographic Details
Main Authors: Hironori Bando, Naoya Sakaguchi, Youngae Lee, Ariel Pradipta, Ji Su Ma, Shun Tanaka, De-Hua Lai, Jianfa Liu, Zhao-Rong Lun, Yoshifumi Nishikawa, Miwa Sasai, Masahiro Yamamoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
IFN-γ
IDO1
IDO2
virulence
human
TgIST
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02073/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02073/full

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