Differential Expression of IRS-1 and IRS-2 in Uterine Leiomyosarcomas with Distinct Oncogenic Phenotypes: Lack of Correlation with Downstream Signaling Events

Differential Expression of IRS-1 and IRS-2 in Uterine Leiomyosarcomas with Distinct Oncogenic Phenotypes: Lack of Correlation with Downstream Signaling Events

Purpose: Insulin receptor substrates (IRSs) are essential for insulin-induced mitogenic effects on several cell types but they also are involved in cell transformation.We investigated whether the differential constitutive expression and potential distinct downstream signaling events of IRS-1 and IRS...

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Bibliographic Details
Main Authors: Alfonso Colombatti, Pietro Russo, Marta Cervi, Laura Bogetto, Bruna Wassermann, Fabrizio Mainiero, Paola Spessotto
Format: Article
Language:English
Published: Hindawi Limited 2002-01-01
Series:Sarcoma
Online Access:http://dx.doi.org/10.1080/1357714021000065387

Internet

http://dx.doi.org/10.1080/1357714021000065387

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