Physiological cyclic hydrostatic pressure induces osteogenic lineage commitment of human bone marrow stem cells: a systematic study

Physiological cyclic hydrostatic pressure induces osteogenic lineage commitment of human bone marrow stem cells: a systematic study

Abstract Background Physical loading is necessary to maintain bone tissue integrity. Loading-induced fluid shear is recognised as one of the most potent bone micromechanical cues and has been shown to direct stem cell osteogenesis. However, the effect of pressure transients, which drive fluid flow,...

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Bibliographic Details
Main Authors: Elena Stavenschi, Michele A. Corrigan, Gillian P. Johnson, Mathieu Riffault, David A. Hoey
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cell
Bone
Mechanobiology
Osteogenic differentiation
Bioreactor
Online Access:http://link.springer.com/article/10.1186/s13287-018-1025-8

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http://link.springer.com/article/10.1186/s13287-018-1025-8

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