Back-to-Germline (B2G) Procedure for Antibody Devolution

Back-to-Germline (B2G) Procedure for Antibody Devolution

Bispecific antibodies (bsAbs) with avidity-enhanced specificity can be used to address target cells with increased specificity, ideally binding efficiently to cells that express two cognate antigens, yet not to cells that express only one of those. Building blocks required to generate such bsAbs are...

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Bibliographic Details
Main Authors: Anja Schrade, Alexander Bujotzek, Christian Spick, Martina Wagner, Johannes Goerl, Xenia Wezler, Guy Georges, Roland E. Kontermann, Ulrich Brinkmann
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Antibodies
Subjects:
protein engineering
antibody
maturation
affinity
structure
antigen binding
Online Access:https://www.mdpi.com/2073-4468/8/3/45

Internet

https://www.mdpi.com/2073-4468/8/3/45

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