Safety, tolerability, and biomarkers of the treatment of mice with aerosolized toll-like receptor ligands

Safety, tolerability, and biomarkers of the treatment of mice with aerosolized toll-like receptor ligands

We have previously discovered a synergistically therapeutic combination of two Toll-like receptor (TLR) ligands, an oligodeoxynucleotide (ODN) and Pam2CSK4. Aerosolization of these ligands stimulates innate immunity within the lungs to prevent pneumonia from bacterial and viral pathogens. Here we ex...

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Bibliographic Details
Main Authors: Victoria eAlfaro, David L. Goldblatt, Gabriella R. Valverde, Mark eMunsell, Lee J. Quinton, Adam K. Walker, Robert eDantzer, Atul eVaradhachary, Brenton L. Scott, Scott E. Evans, Michael J. Tuvim, Burton F Dickey
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Pharmacology
Subjects:
Pneumonia
innate immunity
Toll-like receptor
aerosol
lipopeptide
oligodeoxynucleotide
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00008/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00008/full

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