Serum antibodies against CD28-- a new potential marker of dismal prognosis in melanoma patients.

BACKGROUND: Autoantibodies against CD28 have been found in patients with autoimmune and atopic diseases. These antibodies may act as superagonists and activate T cells but may also be antagonistic or induce immunosuppressive effects by activating regulatory T cells. Autoimmunity in melanoma patients...

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Bibliographic Details
Main Authors: Rebecca Körner, Klaus-Dieter Preuss, Natalie Fadle, Darius Madjidi, Frank Neumann, Lennart Bergeler, Stefan Gräber, Cornelia S L Müller, Frank Grünhage, Michael Pfreundschuh, Frank Lammert, Thomas Vogt, Claudia Pföhler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3590176?pdf=render