Functional, Antigen-Specific Stem Cell Memory (TSCM) CD4+ T Cells Are Induced by Human Mycobacterium tuberculosis Infection

Functional, Antigen-Specific Stem Cell Memory (TSCM) CD4+ T Cells Are Induced by Human Mycobacterium tuberculosis Infection

BackgroundMaintenance of long-lasting immunity is thought to depend on stem cell memory T cells (TSCM), which have superior self-renewing capacity, longevity and proliferative potential compared with central memory (TCM) or effector (TEFF) T cells. Our knowledge of TSCM derives primarily from studie...

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Bibliographic Details
Main Authors: Cheleka A. M. Mpande, One B. Dintwe, Munyaradzi Musvosvi, Simbarashe Mabwe, Nicole Bilek, Mark Hatherill, Elisa Nemes, Thomas J. Scriba, The SATVI Clinical Immunology Team, Cynthia Ontong, Elizabeth Filander, Fadia Alexander, Hadn Africa, Janelle Botes, Lebohang Makhethe, Lungisa Jaxa, Marcia Steyn, Noncedo Xoyana, Rachel Oelfose, Sindile Matiwane
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
TSCM
Mycobacterium tuberculosis
memory T cells
QuantiFERON conversion
LTBI
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00324/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00324/full

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