Combined Pharmacophore Modeling, Docking, and 3D-QSAR Studies of PLK1 Inhibitors

Combined Pharmacophore Modeling, Docking, and 3D-QSAR Studies of PLK1 Inhibitors

Polo-like kinase 1, an important enzyme with diverse biological actions in cell mitosis, is a promising target for developing novel anticancer drugs. A combined molecular docking, structure-based pharmacophore modeling and three-dimensional quantitative structure-activity relationship (3D-QSAR) stud...

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Bibliographic Details
Main Authors: Tao Lu, Liang Zhang, Yi-Ping Gao, Pei Yang, Hao-Liang Yuan, Shan-Liang Sun, Shuai Lu, Ya-Dong Chen, Hai-Chun Liu
Format: Article
Language:English
Published: MDPI AG 2011-12-01
Series:International Journal of Molecular Sciences
Subjects:
PLK1
3D-QSAR
pharmacophore
molecular docking
Online Access:http://www.mdpi.com/1422-0067/12/12/8713/

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http://www.mdpi.com/1422-0067/12/12/8713/

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