Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer

Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer

In bladder, loss of mammalian Sonic Hedgehog (Shh) accompanies progression to invasive urothelial carcinoma, but the molecular mechanisms underlying this cancer-initiating event are poorly defined. Here, we show that loss of Shh results from hypermethylation of the CpG shore of the Shh gene, and tha...

Full description

Bibliographic Details
Main Authors: SungEun Kim, Yubin Kim, JungHo Kong, Eunjee Kim, Jae Hyeok Choi, Hyeong Dong Yuk, HyeSun Lee, Hwa-Ryeon Kim, Kyoung-Hwa Lee, Minyong Kang, Jae-Seok Roe, Kyung Chul Moon, Sanguk Kim, Ja Hyeon Ku, Kunyoo Shin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
hedgehog signaling
tumor stroma
cancer subtype
bladder cancer
epigenetics
BMP signaling
Online Access:https://elifesciences.org/articles/43024

Internet

https://elifesciences.org/articles/43024

Similar Items