Heme oxygenase-1 deficiency presenting with interstitial lung disease and hemophagocytic flares

Heme oxygenase-1 deficiency presenting with interstitial lung disease and hemophagocytic flares

Abstract Background Heme oxygenase-1 (HMOX1) catalyzes the metabolism of heme into carbon monoxide, ferrous iron, and biliverdin. Through biliverdin reductase, biliverdin becomes bilirubin. HMOX1-deficiency is a rare autosomal recessive disorder with hallmark features of direct antibody negative hem...

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Bibliographic Details
Main Authors: Alice S. Chau, Bonnie L. Cole, Jason S. Debley, Kabita Nanda, Aaron B. I. Rosen, Michael J. Bamshad, Deborah A. Nickerson, Troy R. Torgerson, Eric J. Allenspach
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Pediatric Rheumatology Online Journal
Subjects:
HMOX1
Heme oxygenase-1
HO-1
NSIP
Systemic juvenile idiopathic arthritis
Macrophage activation syndrome
Online Access:http://link.springer.com/article/10.1186/s12969-020-00474-1

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http://link.springer.com/article/10.1186/s12969-020-00474-1

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