Abnormalities of hair structure and skin histology derived from CRISPR/Cas9-based knockout of phospholipase C-delta 1 in mice

Abnormalities of hair structure and skin histology derived from CRISPR/Cas9-based knockout of phospholipase C-delta 1 in mice

Abstract Background Hairless mice have been widely applied in skin-related researches, while hairless pigs will be an ideal model for skin-related study and other biomedical researches because of the similarity of skin structure with humans. The previous study revealed that hairlessness phenotype in...

Full description

Bibliographic Details
Main Authors: Yu-Min Liu, Wei Liu, Jun-Shuang Jia, Bang-Zhu Chen, Heng-Wei Chen, Yu Liu, Ya-Nan Bie, Peng Gu, Yan Sun, Dong Xiao, Wei-Wang Gu
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Translational Medicine
Subjects:
Phospholipase C-delta 1 (PLCD1)
Nude mice
Tibet minipigs
CRISPR/Cas9 technology
Hairless
Online Access:http://link.springer.com/article/10.1186/s12967-018-1512-9

Internet

http://link.springer.com/article/10.1186/s12967-018-1512-9

Similar Items