South-East Asian strains of Plasmodium falciparum display higher ratio of non-synonymous to synonymous polymorphisms compared to African strains [version 2; referees: 1 approved, 2 approved with reservations, 1 not approved]
Resistance to frontline anti-malarial drugs, including artemisinin, has repeatedly arisen in South-East Asia, but the reasons for this are not understood. Here we test whether evolutionary constraints on Plasmodium falciparum strains from South-East Asia differ from African strains. We find a signif...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2016-10-01
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| Series: | F1000Research |
| Subjects: | |
| Online Access: | https://f1000research.com/articles/5-1964/v2 |