11-epi-Sinulariolide Acetate Reduces Cell Migration and Invasion of Human Hepatocellular Carcinoma by Reducing the Activation of ERK1/2, p38MAPK and FAK/PI3K/AKT/mTOR Signaling Pathways

11-epi-Sinulariolide Acetate Reduces Cell Migration and Invasion of Human Hepatocellular Carcinoma by Reducing the Activation of ERK1/2, p38MAPK and FAK/PI3K/AKT/mTOR Signaling Pathways

Cancer metastasis is one of the major causes of death in cancer. An active compound, 11-epi-sinulariolide acetate (11-epi-SA), isolated from the cultured soft coral Sinularia flexibilis has been examined for potential anti-cell migration and invasion effects on hepatocellular carcinoma cells (HCC)....

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Bibliographic Details
Main Authors: Jen-Jie Lin, Jui-Hsin Su, Chi-Chu Tsai, Yi-Jen Chen, Ming-Hui Liao, Yu-Jen Wu
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:Marine Drugs
Subjects:
11-epi-sinulariolide acetate
hepatocellular carcinoma
migration
invasion
matrix metalloproteinase
ERK1/2
p38MAPK
Online Access:http://www.mdpi.com/1660-3397/12/9/4783

Internet

http://www.mdpi.com/1660-3397/12/9/4783

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