A Lassa Virus Live-Attenuated Vaccine Candidate Based on Rearrangement of the Intergenic Region

A Lassa Virus Live-Attenuated Vaccine Candidate Based on Rearrangement of the Intergenic Region

Lassa virus (LASV), the causative agent of Lassa fever, infects several hundred thousand people in Western Africa, resulting in many lethal Lassa fever cases. No U.S. Food and Drug Administration-licensed countermeasures are available to prevent or treat LASV infection. We describe the generation of...

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Bibliographic Details
Main Authors: Yingyun Cai, Masaharu Iwasaki, Daisuke Motooka, David X. Liu, Shuiqing Yu, Kurt Cooper, Randy Hart, Ricky Adams, Tracey Burdette, Elena N. Postnikova, Jonathan Kurtz, Marisa St. Claire, Chengjin Ye, Jens H. Kuhn, Luis Martínez-Sobrido, Juan Carlos de la Torre
Format: Article
Language:English
Published: American Society for Microbiology 2020-03-01
Series:mBio
Subjects:
arenaviridae
arenavirid
arenavirus
bunyavirales
bunyavirus
guinea pig
lassa
lassa fever
lassa virus
lasv
lav
live-attenuated vaccine
mammarenavirus
strain 13
vaccine
vhf
viral hemorrhagic fever
intergenic region
igr
reverse genetics
Online Access:https://doi.org/10.1128/mBio.00186-20

Internet

https://doi.org/10.1128/mBio.00186-20

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