ABPP-HT - High-Throughput Activity-Based Profiling of Deubiquitylating Enzyme Inhibitors in a Cellular Context

ABPP-HT - High-Throughput Activity-Based Profiling of Deubiquitylating Enzyme Inhibitors in a Cellular Context

The potency and selectivity of a small molecule inhibitor are key parameters to assess during the early stages of drug discovery. In particular, it is very informative for characterizing compounds in a relevant cellular context in order to reveal potential off-target effects and drug efficacy. Activ...

Full description

Bibliographic Details
Main Authors: Hannah B. L. Jones, Raphael Heilig, Roman Fischer, Benedikt M. Kessler, Adán Pinto-Fernández
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Chemistry
Subjects:
activitomics
activity-based probes
deubiquitylating enzymes
ubiquitin
proteomics
drug discovery
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.640105/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.640105/full

Similar Items