Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases.

Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases.

Eukaryotic protein kinases regulate most cellular functions by phosphorylating targeted protein substrates through a highly conserved catalytic core. In the active state, the catalytic core oscillates between open, intermediate, and closed conformations. Currently, the intramolecular interactions th...

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Bibliographic Details
Main Authors: Hiruy S Meharena, Xiaorui Fan, Lalima G Ahuja, Malik M Keshwani, Christopher L McClendon, Angela M Chen, Joseph A Adams, Susan S Taylor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-11-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC5130182?pdf=render

Internet

http://europepmc.org/articles/PMC5130182?pdf=render

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