Synergistic anti-tumor efficacy of oncolytic influenza viruses and B7-H3 immune- checkpoint inhibitors against IC-resistant lung cancers

Synergistic anti-tumor efficacy of oncolytic influenza viruses and B7-H3 immune- checkpoint inhibitors against IC-resistant lung cancers

Non-small cell lung cancers (NSCLCs) establish a highly immunosuppressive tumor microenvironment supporting cancer growth. To interfere with cancer-mediated immunosuppression, selective immune-checkpoint inhibitors (ICIs) have been approved as a standard-of-care treatment for NSCLCs. However, the ma...

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Bibliographic Details
Main Authors: Dörthe Masemann, Ramona Meissner, Tanja Schied, Brian D Lichty, Ulf R Rapp, Viktor Wixler, Stephan Ludwig
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
lung cancer
oncolytic virus
immune-checkpoint inhibitor
cancer immunosuppression
immunotherapy
Online Access:http://dx.doi.org/10.1080/2162402X.2021.1885778

Internet

http://dx.doi.org/10.1080/2162402X.2021.1885778

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