Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells

Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells

Human SEMAPHORIN 5A (SEMA5A) is an autism susceptibility gene; however, its function in brain development is unknown. In this study, we show that mouse Sema5A negatively regulates synaptogenesis in early, developmentally born, hippocampal dentate granule cells (GCs). Sema5A is strongly expressed by...

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Bibliographic Details
Main Authors: Yuntao Duan, Shih-Hsiu Wang, Juan Song, Yevgeniya Mironova, Guo-li Ming, Alex L Kolodkin, Roman J Giger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-10-01
Series:eLife
Subjects:
synaptogenesi
semaphorin
hippocampus
dentate granule cell
plexin
3D electron microscopy
Online Access:https://elifesciences.org/articles/04390

Internet

https://elifesciences.org/articles/04390

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