Sustained hyperosmolarity increses TGF-ß1 and Egr-1 expression in the rat renal medulla

Sustained hyperosmolarity increses TGF-ß1 and Egr-1 expression in the rat renal medulla

Abstract Background Although TGF-ß and the transcription factor Egr-1 play an important role in both kidney fibrosis and in response to acute changes of renal medullary osmolarity, their role under sustained hypo- or hyperosmolar conditions has not been elucidated. We investigated the effects of chr...

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Bibliographic Details
Main Authors: Miklós M. Mózes, Petra Szoleczky, László Rosivall, Gábor Kökény
Format: Article
Language:English
Published: BMC 2017-07-01
Series:BMC Nephrology
Subjects:
Osmotic stress
Urea
Sodium chloride
Fibrosis
TGF-ß
Egr-1
Online Access:http://link.springer.com/article/10.1186/s12882-017-0626-2

Internet

http://link.springer.com/article/10.1186/s12882-017-0626-2

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