Differential Involvement of ACKR3 C-Tail in β-Arrestin Recruitment, Trafficking and Internalization

Differential Involvement of ACKR3 C-Tail in β-Arrestin Recruitment, Trafficking and Internalization

<b>Background</b>: The atypical chemokine receptor 3 (ACKR3) belongs to the superfamily of G protein-coupled receptors (GPCRs). Unlike classical GPCRs, this receptor does not activate G proteins in most cell types but recruits β-arrestins upon activation. ACKR3 plays an important role in...

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Bibliographic Details
Main Authors: Aurélien Zarca, Claudia Perez, Jelle van den Bor, Jan Paul Bebelman, Joyce Heuninck, Rianna J. F. de Jonker, Thierry Durroux, Henry F. Vischer, Marco Siderius, Martine J. Smit
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cells
Subjects:
GPCR
ACKR3
chemokine receptor
protein phosphorylation
β-arrestins
bioluminescence energy transfer (BRET)
Online Access:https://www.mdpi.com/2073-4409/10/3/618

Internet

https://www.mdpi.com/2073-4409/10/3/618

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