Preserving Genome Integrity during the Early Embryonic DNA Replication Cycles

During the very early stages of embryonic development chromosome replication occurs under rather challenging conditions, including a very short cell cycle, absence of transcription, a relaxed DNA damage response and, in certain animal species, a highly contracted S-phase. This raises the puzzling qu...

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Bibliographic Details
Main Authors: Chames Kermi, Antoine Aze, Domenico Maiorano
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Genes
Subjects:
Online Access:https://www.mdpi.com/2073-4425/10/5/398