Interleukin-5 in the Pathophysiology of Severe Asthma

Interleukin-5 in the Pathophysiology of Severe Asthma

Interleukin-5 (IL-5) exerts a central pathogenic role in differentiation, recruitment, survival, and degranulation of eosinophils. Indeed, during the last years, significant advances have been made in our understanding of the cellular and molecular mechanisms underlying the powerful actions of IL-5...

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Bibliographic Details
Main Authors: Corrado Pelaia, Giovanni Paoletti, Francesca Puggioni, Francesca Racca, Girolamo Pelaia, Giorgio Walter Canonica, Enrico Heffler
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Physiology
Subjects:
IL-5
eosinophils
T2-high asthma
mepolizumab
reslizumab
benralizumab
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01514/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.01514/full

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