The mechanism of increased intestinal palmitic acid absorption and its impact on hepatic stellate cell activation in nonalcoholic steatohepatitis

The mechanism of increased intestinal palmitic acid absorption and its impact on hepatic stellate cell activation in nonalcoholic steatohepatitis

Abstract Dietary palmitic acid (PA) promotes liver fibrosis in patients with nonalcoholic steatohepatitis (NASH). Herein, we clarified the intestinal absorption kinetics of dietary PA and effect of trans-portal PA on the activation of hepatic stellate cells (HSCs) involved in liver fibrosis in NASH....

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Main Authors: Masakazu Hanayama, Yasunori Yamamoto, Hiroki Utsunomiya, Osamu Yoshida, Shuang Liu, Masaki Mogi, Bunzo Matsuura, Eiji Takeshita, Yoshiou Ikeda, Yoichi Hiasa
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-92790-z

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https://doi.org/10.1038/s41598-021-92790-z

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