Modeling the human Nav1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade

Modeling the human Nav1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade

Marawan Ahmed,1 Horia Jalily Hasani,1,* Aravindhan Ganesan,1,* Michael Houghton,2–4 Khaled Barakat1–3 1Faculty of Pharmacy and Pharmaceutical Sciences, 2Li Ka Shing Institute of Virology, 3Li Ka Shing Applied Virology Institute, 4Department of Medical Microbiology and Immunology...

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Bibliographic Details
Main Authors: Ahmed M, Jalily Hasani H, Ganesan A, Houghton M, Barakat K
Format: Article
Language:English
Published: Dove Medical Press 2017-08-01
Series:Drug Design, Development and Therapy
Subjects:
Sodium ion channel
voltage gated sodium channel
steered molecular dynamics
cardiotoxicity
hNav1.5
channel blockers.
Online Access:https://www.dovepress.com/modeling-the-human-nav15-sodium-channel-structural-and-mechanistic-ins-peer-reviewed-article-DDDT

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https://www.dovepress.com/modeling-the-human-nav15-sodium-channel-structural-and-mechanistic-ins-peer-reviewed-article-DDDT

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