Stability of BSE infectivity towards heat treatment even after proteolytic removal of prion protein

Stability of BSE infectivity towards heat treatment even after proteolytic removal of prion protein

Abstract The unconventional infectious agents of transmissible spongiform encephalopathies (TSEs) are prions. Their infectivity co-appears with PrPSc, aberrant depositions of the host’s cellular prion protein (PrPC). Successive heat treatment in the presence of detergent and proteolysis by a keratin...

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Bibliographic Details
Main Authors: Jan P. M. Langeveld, Anne Balkema-Buschmann, Dieter Becher, Achim Thomzig, Romolo Nonno, Olivier Andréoletti, Aart Davidse, Michele A. Di Bari, Laura Pirisinu, Umberto Agrimi, Martin H. Groschup, Michael Beekes, Jason Shih
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Veterinary Research
Subjects:
Prion
PrP
Molecular mechanism
BSE
Zoonotic
Infectivity
Online Access:https://doi.org/10.1186/s13567-021-00928-8

Internet

https://doi.org/10.1186/s13567-021-00928-8

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