Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation
Prereplicative complex (pre-RC) formation during G1 is fundamental for cell replication. Here the authors report a role for cyclin K in regulating pre-RC formation in mammalian cells by affecting cyclin E1 activity.
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2018-05-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-04258-w |
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doaj-aa0bfdb189444623bd43e33efbfa2ec82021-05-11T10:28:27ZengNature Publishing GroupNature Communications2041-17232018-05-019111510.1038/s41467-018-04258-wCyclin K regulates prereplicative complex assembly to promote mammalian cell proliferationTingjun Lei0Peixuan Zhang1Xudong Zhang2Xue Xiao3Jingli Zhang4Tong Qiu5Qian Dai6Yujun Zhang7Ling Min8Qian Li9Rutie Yin10Ping Ding11Ni Li12Yi Qu13Dezhi Mu14Jun Qin15Xiaofeng Zhu16Zhi-Xiong Xiao17Qintong Li18Department of Obstetrics and Gynecology, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan UniversityDepartment of Obstetrics and Gynecology, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan UniversityDepartment of Obstetrics and Gynecology, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan UniversityDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan UniversityDepartment of Pathology, Hospital 363 of Aviation Industry Corporation of ChinaDepartment of Pediatrics, West China Second University Hospital, Sichuan UniversityDepartment of Pediatrics, West China Second University Hospital, Sichuan UniversityCenter of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan UniversityDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan UniversityDepartment of Pathology, Hospital 363 of Aviation Industry Corporation of ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan UniversitySichuan Cunde TherapeuticsKey Laboratory of Stem Cell Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of SciencesDepartment of Pediatrics, West China Second University Hospital, Sichuan UniversityDepartment of Pediatrics, West China Second University Hospital, Sichuan UniversityKey Laboratory of Stem Cell Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of SciencesDepartment of Obstetrics and Gynecology, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan UniversityCenter of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan UniversityDepartment of Obstetrics and Gynecology, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, College of Life Sciences, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan UniversityPrereplicative complex (pre-RC) formation during G1 is fundamental for cell replication. Here the authors report a role for cyclin K in regulating pre-RC formation in mammalian cells by affecting cyclin E1 activity.https://doi.org/10.1038/s41467-018-04258-w |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tingjun Lei Peixuan Zhang Xudong Zhang Xue Xiao Jingli Zhang Tong Qiu Qian Dai Yujun Zhang Ling Min Qian Li Rutie Yin Ping Ding Ni Li Yi Qu Dezhi Mu Jun Qin Xiaofeng Zhu Zhi-Xiong Xiao Qintong Li |
spellingShingle |
Tingjun Lei Peixuan Zhang Xudong Zhang Xue Xiao Jingli Zhang Tong Qiu Qian Dai Yujun Zhang Ling Min Qian Li Rutie Yin Ping Ding Ni Li Yi Qu Dezhi Mu Jun Qin Xiaofeng Zhu Zhi-Xiong Xiao Qintong Li Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation Nature Communications |
author_facet |
Tingjun Lei Peixuan Zhang Xudong Zhang Xue Xiao Jingli Zhang Tong Qiu Qian Dai Yujun Zhang Ling Min Qian Li Rutie Yin Ping Ding Ni Li Yi Qu Dezhi Mu Jun Qin Xiaofeng Zhu Zhi-Xiong Xiao Qintong Li |
author_sort |
Tingjun Lei |
title |
Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation |
title_short |
Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation |
title_full |
Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation |
title_fullStr |
Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation |
title_full_unstemmed |
Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation |
title_sort |
cyclin k regulates prereplicative complex assembly to promote mammalian cell proliferation |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2018-05-01 |
description |
Prereplicative complex (pre-RC) formation during G1 is fundamental for cell replication. Here the authors report a role for cyclin K in regulating pre-RC formation in mammalian cells by affecting cyclin E1 activity. |
url |
https://doi.org/10.1038/s41467-018-04258-w |
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