EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2.

EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2.

EMMPRIN's expression in melanoma tissue was reported to be predictive of poor prognosis. Here we demonstrate that EMMPRIN up-regulated VEGF receptor-2 (VEGFR-2) in two different primary melanoma cell lines and consequently increased migration and proliferation of these cells while inhibiting th...

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Bibliographic Details
Main Authors: Faten Bougatef, Suzanne Menashi, Farah Khayati, Benyoussef Naïmi, Raphaël Porcher, Marie-Pierre Podgorniak, Guy Millot, Anne Janin, Fabien Calvo, Céleste Lebbé, Samia Mourah
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20824203/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20824203/?tool=EBI

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