Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance

Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance

Serine hydrolases are a large family of multifunctional enzymes known to influence obesity. Here, we performed activity-based protein profiling to assess the functional level of serine hydrolases in liver biopsies from lean and obese humans in order to gain mechanistic insight into the pathophysiolo...

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Bibliographic Details
Main Authors: Maxwell A. Ruby, Julie Massart, Devon M. Hunerdosse, Milena Schönke, Jorge C. Correia, Sharon M. Louie, Jorge L. Ruas, Erik Näslund, Daniel K. Nomura, Juleen R. Zierath
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
obesity
hepatic steatosis
carboxylesterase
lipidomics
insulin resistance
activity-based protein profiling
inflammation
diacylglycerol
serine hydrolase
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716317776

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http://www.sciencedirect.com/science/article/pii/S2211124716317776

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