Lactate Induces Pro-tumor Reprogramming in Intratumoral Plasmacytoid Dendritic Cells

Lactate Induces Pro-tumor Reprogramming in Intratumoral Plasmacytoid Dendritic Cells

Plasmacytoid dendritic cells are the most efficient producers of type I interferons, viz. IFNα, in the body and thus have the ability to influence anti-tumor immune responses. But repression of effective intra-tumoral pDC activation is a key immuno-evasion strategy exhibited in tumors—tumor-recruite...

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Bibliographic Details
Main Authors: Deblina Raychaudhuri, Roopkatha Bhattacharya, Bishnu Prasad Sinha, Chinky Shiu Chen Liu, Amrit Raj Ghosh, Oindrila Rahaman, Purbita Bandopadhyay, Jafar Sarif, Ranit D'Rozario, Santu Paul, Anirban Das, Diptendra K. Sarkar, Samit Chattopadhyay, Dipyaman Ganguly
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
breast cancer
FoxP3+ T cells
lactate
plasmacytoid dendritic cells
type I IFN
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01878/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01878/full

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