BKV Clearance Time Correlates With Exhaustion State and T-Cell Receptor Repertoire Shape of BKV-Specific T-Cells in Renal Transplant Patients

BKV Clearance Time Correlates With Exhaustion State and T-Cell Receptor Repertoire Shape of BKV-Specific T-Cells in Renal Transplant Patients

Reactivation of the BK polyomavirus is known to lead to severe complications in kidney transplant patients. The current treatment strategy relies on decreasing the immunosuppression to allow the immune system to clear the virus. Recently, we demonstrated a clear association between the resolution of...

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Bibliographic Details
Main Authors: Ulrik Stervbo, Mikalai Nienen, Benjamin J. D. Weist, Leon Kuchenbecker, Jochen Hecht, Patrizia Wehler, Timm H. Westhoff, Petra Reinke, Nina Babel
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
BKV
T-cell
TCR repertoire
exhaustion
diversity
immunology
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00767/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00767/full

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