Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice

The allele E4 of apolipoprotein E (apoE) is an important risk factor for Alzheimer’s disease (AD) and the chronic brain inflammation which is associated with AD is more pronounced in subjects who carry this allele. In the present study, we employed mice transgenic for the human apoE isoforms apoE3 o...

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Bibliographic Details
Main Authors: Gal Ophir, Sigal Meilin, Margalit Efrati, Joab Chapman, Dimitri Karussis, Allen Roses, Daniel M Michaelson
Format: Article
Published: Elsevier 2003-02-01
Series:Neurobiology of Disease
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