Transcriptional repressive H3K9 and H3K27 methylations contribute to DNMT1-mediated DNA methylation recovery.

Transcriptional repressive H3K9 and H3K27 methylations contribute to DNMT1-mediated DNA methylation recovery.

DNA methylation and histone modifications are two major epigenetic events regulating gene expression and chromatin structure, and their alterations are linked to human carcinogenesis. DNA methylation plays an important role in tumor suppressor gene inactivation, and can be revised by DNA methylation...

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Bibliographic Details
Main Authors: Chun-Ming Wong, Carmen Chak-Lui Wong, Yeung-Lam Ng, Sandy Leung-Kuen Au, Frankie Chi-Fat Ko, Irene Oi-Lin Ng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3035659?pdf=render

Internet

http://europepmc.org/articles/PMC3035659?pdf=render

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