Neurites containing the neurofilament-triplet proteins are selectively vulnerable to cytoskeletal pathology in Alzheimer’s disease and transgenic mouse models

Amyloid-β plaque accumulation in Alzheimer’s disease (AD) is associated with dystrophic neurite formation and synapse loss in principal neurons, but interneuron pathology is less clearly characterised. We compared the responses of neuronal processes immunoreactive for either neurofilament triplet (N...

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Bibliographic Details
Main Authors: Stanislaw eMitew, Matthew T.K. Kirkcaldie, Tracey C Dickson, James C Vickers
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Neuroanatomy
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnana.2013.00030/full