Helicobacter pylori CagA: from pathogenic mechanisms to its use as an anti-cancer vaccine

Helicobacter pylori CagA: from pathogenic mechanisms to its use as an anti-cancer vaccine

Helicobacter pylori colonizes the gastric mucosa of more than 50% of the human population, causing chronic inflammation, which however is largely asymptomatic. Nevertheless, H. pylori-infected subjects can develop chronic gastritis, peptic ulcer, gastric mucosa-associated lymphoid tissue (MALT) lymp...

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Bibliographic Details
Main Authors: Markus eStein, Paolo eRuggiero, Rino eRappuoli, Fabio eBagnoli
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Immunology
Subjects:
Helicobacter pylori
Vaccines
Cancer
Epithelial to Mesenchymal transition
CagA
type IV secretion system
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00328/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00328/full

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