Using the geometric average hazard ratio in sample size calculation for time-to-event data with composite endpoints

Using the geometric average hazard ratio in sample size calculation for time-to-event data with composite endpoints

Abstract Background Sample size calculation is a key point in the design of a randomized controlled trial. With time-to-event outcomes, it’s often based on the logrank test. We provide a sample size calculation method for a composite endpoint (CE) based on the geometric average hazard ratio (gAHR) i...

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Bibliographic Details
Main Authors: Jordi Cortés Martínez, Ronald B. Geskus, KyungMann Kim, Guadalupe Gómez Melis
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Medical Research Methodology
Subjects:
Treatment Effect
Composite endpoint
Randomized Controlled Trial
Progression-Free Survival
Simulation
Copula
Online Access:https://doi.org/10.1186/s12874-021-01286-x

Internet

https://doi.org/10.1186/s12874-021-01286-x

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