BET inhibitor JQ1 suppresses cell proliferation via inducing autophagy and activating LKB1/AMPK in bladder cancer cells

BET inhibitor JQ1 suppresses cell proliferation via inducing autophagy and activating LKB1/AMPK in bladder cancer cells

Abstract Aim JQ1, a BET bromodomain inhibitor, is a promising therapeutic approach for bladder cancer (BC). Our study aimed to determine whether autophagy is induced by JQ1 and its potential role toward proliferation in BC. Methods Cell proliferation was determined by methylthiazolyldiphenyl‐tetrazo...

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Bibliographic Details
Main Authors: Feng Li, Chao Yang, Hai‐Bao Zhang, Jianbin Ma, Jing Jia, Xiaoshuang Tang, Jin Zeng, Tie Chong, Xinyang Wang, Dalin He, Peng Guo
Format: Article
Language:English
Published: Wiley 2019-08-01
Series:Cancer Medicine
Subjects:
AMPKα
autophagy
bladder cancer
JQ1
Online Access:https://doi.org/10.1002/cam4.2385

Internet

https://doi.org/10.1002/cam4.2385

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