Characterization of the σ-Pore in Mutant hKv1.3 Potassium Channels

Background/Aims: The replacement of the amino acid valine at position 388 (Shaker position 438) in hKv1.3 channels or at the homologue position 370 in hKv1.2 channels resulted in a channel with two different ion conducting pathways: One pathway was the central, potassium-selective α-pore, that was s...

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Bibliographic Details
Main Authors: Pavel Tyutyaev, Stephan Grissmer
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
Online Access:https://www.karger.com/Article/FullText/488840