A Novel 1,8-Naphthyridine-2-Carboxamide Derivative Attenuates Inflammatory Responses and Cell Migration in LPS-Treated BV2 Cells via the Suppression of ROS Generation and TLR4/Myd88/NF-κB Signaling Pathway

A Novel 1,8-Naphthyridine-2-Carboxamide Derivative Attenuates Inflammatory Responses and Cell Migration in LPS-Treated BV2 Cells via the Suppression of ROS Generation and TLR4/Myd88/NF-κB Signaling Pathway

Novel 1,8-naphthyridine-2-carboxamide derivatives with various substituents (HSR2101-HSR2113) were synthesized and evaluated for their effects on the production of pro-inflammatory mediators and cell migration in lipopolysaccharide (LPS)-treated BV2 microglial cells. Among the tested compounds, HSR2...

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Bibliographic Details
Main Authors: Phuong Linh Nguyen, Bich Phuong Bui, Heesoon Lee, Jungsook Cho
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
1,8-naphthyridine-2-carboxamides
nuclear factor-kappa B
Toll-like receptor
BV2 microglial cells
inflammatory mediators
cell migration
Online Access:https://www.mdpi.com/1422-0067/22/5/2527

Internet

https://www.mdpi.com/1422-0067/22/5/2527

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