Clarin‐2 is essential for hearing by maintaining stereocilia integrity and function
Abstract Hearing relies on mechanically gated ion channels present in the actin‐rich stereocilia bundles at the apical surface of cochlear hair cells. Our knowledge of the mechanisms underlying the formation and maintenance of the sound‐receptive structure is limited. Utilizing a large‐scale forward...
Main Authors: | Lucy A Dunbar, Pranav Patni, Carlos Aguilar, Philomena Mburu, Laura Corns, Helena RR Wells, Sedigheh Delmaghani, Andrew Parker, Stuart Johnson, Debbie Williams, Christopher T Esapa, Michelle M Simon, Lauren Chessum, Sherylanne Newton, Joanne Dorning, Prashanthini Jeyarajan, Susan Morse, Andrea Lelli, Gemma F Codner, Thibault Peineau, Suhasini R Gopal, Kumar N Alagramam, Ronna Hertzano, Didier Dulon, Sara Wells, Frances M Williams, Christine Petit, Sally J Dawson, Steve DM Brown, Walter Marcotti, Aziz El‐Amraoui, Michael R Bowl |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2019-09-01
|
Series: | EMBO Molecular Medicine |
Subjects: | |
Online Access: | https://doi.org/10.15252/emmm.201910288 |
Similar Items
-
Stereocilia Rootlets: Actin-Based Structures That Are Essential for Structural Stability of the Hair Bundle
by: Itallia Pacentine, et al.
Published: (2020-01-01) -
Mechanotransduction current is essential for stability of the transducing stereocilia in mammalian auditory hair cells
by: A Catalina Vélez-Ortega, et al.
Published: (2017-03-01) -
Stereocilia Morphogenesis and Maintenance is Dependent on the Dynamics of Actin Cytoskeletal Proteins
by: Roy, Pallabi
Published: (2019) -
The 133-kDa N-terminal domain enables myosin 15 to maintain mechanotransducing stereocilia and is essential for hearing
by: Qing Fang, et al.
Published: (2015-08-01) -
Murine GRXCR1 Has a Different Function Than GRXCR2 in the Morphogenesis of Stereocilia
by: Chang Liu, et al.
Published: (2021-07-01)