Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice.

Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice.

How congenital defects causing genome instability can result in the pleiotropic symptoms reminiscent of aging but in a segmental and accelerated fashion remains largely unknown. Most segmental progerias are associated with accelerated fibroblast senescence, suggesting that cellular senescence is a l...

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Bibliographic Details
Main Authors: Marieke van de Ven, Jaan-Olle Andressoo, Valerie B Holcomb, Marieke von Lindern, Willeke M C Jong, Chris I De Zeeuw, Yousin Suh, Paul Hasty, Jan H J Hoeijmakers, Gijsbertus T J van der Horst, James R Mitchell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-12-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC1698946?pdf=render

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http://europepmc.org/articles/PMC1698946?pdf=render

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