Proteomic analysis of hippocampal dentate granule cells in frontotemporal lobar degeneration: Application of laser capture technology.

Proteomic analysis of hippocampal dentate granule cells in frontotemporal lobar degeneration: Application of laser capture technology.

Frontotemporal lobar degeneration (FTLD) is the most common cause of dementia with pre-senile onset, accounting for as many as 20% of cases. A common subset of FTLD cases is characterized by the presence of ubiquitinated inclusions in vulnerable neurons (FTLD-U). While the pathophysiological mechani...

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Bibliographic Details
Main Authors: Yair M. Gozal, Eric B. Dammer, Duc M. Duong, Dongmei eCheng, Marla eGearing, Howard D. Rees, Junmin ePeng, James J. Lah, Allan I. Levey
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-04-01
Series:Frontiers in Neurology
Subjects:
Dementia
Laser Capture Microdissection
Mass Spectrometry
Ubiquitin
neurodegeneration
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2011.00024/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fneur.2011.00024/full

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