The inner foreskin of healthy males at risk of HIV infection harbors epithelial CD4+ CCR5+ cells and has features of an inflamed epidermal barrier.

Male circumcision provides partial protection against multiple sexually transmitted infections (STIs), including HIV, but the mechanisms are not fully understood. To examine potential vulnerabilities in foreskin epithelial structure, we used Wilcoxon paired tests adjusted using the false discovery r...

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Bibliographic Details
Main Authors: Maria P Lemos, Javier R Lama, Shelly T Karuna, Youyi Fong, Silvia M Montano, Carmela Ganoza, Raphael Gottardo, Jorge Sanchez, M Juliana McElrath
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4182607?pdf=render