Glucose Overload Inhibits Glutamatergic Synaptic Transmission: A Novel Role for CREB-Mediated Regulation of Synaptotagmins 2 and 4

Glucose Overload Inhibits Glutamatergic Synaptic Transmission: A Novel Role for CREB-Mediated Regulation of Synaptotagmins 2 and 4

Glucose metabolism derangement is critically involved in the age-related memory loss but the underlying molecular mechanisms are still poorly understood. In a mouse model of type 1 diabetes we found memory impairment associated with inhibition of the transcription factor CREB and alteration of pre-...

Full description

Bibliographic Details
Main Authors: Cristian Ripoli, Matteo Spinelli, Francesca Natale, Salvatore Fusco, Claudio Grassi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
synaptic vesicle release
hippocampus
type 1 diabetes
hyperglycaemia
synaptic proteins
memory loss
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00810/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00810/full

Similar Items