Quetiapine inhibits microglial activation by neutralizing abnormal STIM1 mediated intercellular calcium homeostasis and promotes myelin repair in a cuprizone -induced mouse model of de-myelination

Quetiapine inhibits microglial activation by neutralizing abnormal STIM1 mediated intercellular calcium homeostasis and promotes myelin repair in a cuprizone -induced mouse model of de-myelination

Microglial activation has been considered as a crucial process in the pathogenesis of neuro-inflammation and psychiatric disorders. Several antipsychotic drugs have been shown to display inhibitory effects on microglial activation in vitro, possibly through the suppression of elevated intracellular...

Full description

Bibliographic Details
Main Authors: Hanzhi eWang, Shubao eLiu, Yanping eTian, Xiyan eWu, Chengren eLi, Yangtao eHe, Michael eNamaka, Jiming eKong, Hongli eLi, Lan eXiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
calcium homeostasis
microglial activation
quetiapine
STIM1
store-operated calcium entry
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00492/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00492/full

Similar Items