The constitutively active V2 receptor mutants conferring NSIAD are weakly sensitive to agonist and antagonist regulation.

The constitutively active V2 receptor mutants conferring NSIAD are weakly sensitive to agonist and antagonist regulation.

Patients having the nephrogenic syndrome of inappropriate antidiuresis present either the R137C or R137L V2 mutated receptor. While the clinical features have been characterized, the molecular mechanisms of functioning of these two mutants remain elusive. In the present study, we compare the pharmac...

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Main Authors: Julie Tenenbaum, Mohammed A Ayoub, Sanja Perkovska, Anne-Laure Adra-Delenne, Christiane Mendre, Bruno Ranchin, Giamperro Bricca, Ghislaine Geelen, Bernard Mouillac, Thierry Durroux, Denis Morin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2792721?pdf=render

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http://europepmc.org/articles/PMC2792721?pdf=render

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