The Role of Pre-existing Cross-Reactive Central Memory CD4 T-Cells in Vaccination With Previously Unseen Influenza Strains

The Role of Pre-existing Cross-Reactive Central Memory CD4 T-Cells in Vaccination With Previously Unseen Influenza Strains

Influenza vaccination is a common approach to prevent seasonal and pandemic influenza. Pre-existing antibodies against close viral strains might impair antibody formation against previously unseen strains–a process called original antigenic sin. The role of this pre-existing cellular immunity in thi...

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Bibliographic Details
Main Authors: Mikalai Nienen, Ulrik Stervbo, Felix Mölder, Sviatlana Kaliszczyk, Leon Kuchenbecker, Ludmila Gayova, Brunhilde Schweiger, Karsten Jürchott, Jochen Hecht, Avidan U. Neumann, Sven Rahmann, Timm Westhoff, Petra Reinke, Andreas Thiel, Nina Babel
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
influenza vaccination
vaccination efficacy
pre-existing cross-reactive T-cells
central memory T-cell
clonotype diversity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00593/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00593/full

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