The Role of Pre-existing Cross-Reactive Central Memory CD4 T-Cells in Vaccination With Previously Unseen Influenza Strains
Influenza vaccination is a common approach to prevent seasonal and pandemic influenza. Pre-existing antibodies against close viral strains might impair antibody formation against previously unseen strains–a process called original antigenic sin. The role of this pre-existing cellular immunity in thi...
Main Authors: | Mikalai Nienen, Ulrik Stervbo, Felix Mölder, Sviatlana Kaliszczyk, Leon Kuchenbecker, Ludmila Gayova, Brunhilde Schweiger, Karsten Jürchott, Jochen Hecht, Avidan U. Neumann, Sven Rahmann, Timm Westhoff, Petra Reinke, Andreas Thiel, Nina Babel |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-04-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00593/full |
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